Prevention of mesothelioma

Prevention mesotheliomas main and most effective way is to reverse the spread of dust in the workplace environment. The most effective prevention of the occurrence of mesothelioma in workers is to avoid exposure.

Slovak Ministry of Health has published the "Regulation No.4/1985 Bull. of the Ministry helath on helath Principles to be kept in Handling and Work with Chemical carcinogens, Regulation No. 8/1990 Bull. of the Ministry of Helath on Control of Asbestos and PCBs ". The main principle of the rule is the use of asbestos was banned in all things, which can lead to though a little risky substances, production or materials containing asbestos should only be used when other alternatives are not at risk of material can not be used.

Secondary prevention is done by medical personnel (doctors factories, medical units of work, public health institutes) in collaboration with the owners and workers. Prevention, among others, in the form of all workers exposed to asbestos should undergo regular inspections during the period of work particular, including the following does not work at this site again or resign from the job, limiting tobacco smoking,minimize and record job asbestos exposure, early detection, adequate treatment and rehabilitation of health changes associated with asbestos.

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Mesothelioma Treatment

There is no effective treatment for mesothelioma. But good treatment outcome in patients with early stage of mesothelioma. 

Most people use a combination therapy, called multimodal therapy. Handling classics such as surgery, chemotherapy and radiotherapy less effect on curing diseases and life skills. Pleuropneumonektomi radical surgery such as; as single-modality treatment, also showed no improvement on life skills. But management trimodaliti with pleuronektomi ekstrapleural and adjuvant chemotherapy followed by radical external radiation to be hemitoraks help the ability to live up to 5 years by 45% for patients with malignant pleural mesothelioma of epithelial limited and there is no spread to the mediastinum. But radical action is intended only for a particular patient. 

Radiotherapy can not cure, but it is usually used to prevent further infiltration of the tumor and treat chest pain. Chemotherapy did not work, either act alone or in combination with other measures. To improve the ability of malignant pleural mesothelioma survival, new therapeutic strategies try to use the base immunotherapy or gene therapy. Gamma interferon is used intrapleura results are quite good in limited-stage disease. 

Mechanism of action of antitumor of gamma interferon is a complex, inter alia: (1) direct antiproliferative effect on

tumor cells, (2) pleural macrophage activation into cytotoxic to tumor cells, and (3) activation of T lymphocytes and natural killer cells by cytokines released by the macrophages.

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